Scopus: With the rapid development of medical imaging techniques, artificial intelligence (AI) and radiomics have been heralded as the frontiers in medical imaging (MI). AI in MI is the science and engineering of making intelligent imaging machines, especially intelligent computer programs for clinical practices. While the radiomics refers to the high-throughput extraction of a large number of imaging and genetic features from multi-modality data sets and characterizes the region of interests (ROIs) for further analyses of grading, classification, predication, planning and prognosis assessment. The ultimate goal of AI and Radiomics in MI is to improve patient outcomes for better prevention, diagnosis, and treatment of diseases. Therefore, the aim of this special issue is willing to provide the readers with an up-to-date research progress and future development of this field in order to help improve human health.

Improving the speed and accuracy of clinical diagnosis, augmenting clinical decision-making, reducing human error in clinical care, individualizing therapies based on a patient's genomic and metabolomic profiles, differentiating benign from cancerous lesions with impeccable accuracy, identifying likely conditions a person may develop years down the road, spotting early tell-tale signs of an ultrarare disease, intercepting dangerous drug interactions before a patient is given a new medication, yielding real-time insights amidst a raging pandemic to inform optimal treatment of patients infected with a novel human pathogen. These are some of the promises that physicians and researchers look to fulfill using artificial intelligence -- promises poised to transform clinical care, lead to better patient outcomes, and, ultimately, improve human lives. Yet, AI is no silver bullet. It can fall prey to the cognitive fallibilities and blind spots of the humans who design it. AI models can be as imperfect as the data and clinical practices that the machine-learning algorithms are trained on, propagating the very same biases AI was designed to eliminate in the first place. Beyond conceptual and design pitfalls, realizing the potential of AI also requires overcoming systemic hurdles that stand in the way of integrating AI-based technologies into clinical practice.